GWP-042

• Description:

  GWP-042 is a potent inhibitor of mycobacterial alanine dehydrogenase (Ald) Rv2780, with the IC50 of 0.21 μM. GWP-042 has antimicrobial activity against M. tuberculosis infection in vivo[1].

• UNSPSC:

  12352005

• Hazard Statement:

  H302, H315, H319, H335

• Target:

  Bacterial

• Type:

  Reference compound

• Related Pathways:

  Anti-infection

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Infection

• Assay Protocol:

  https://www.medchemexpress.com/gwp-042.html

• Purity:

  99.52

• Solubility:

  H2O : < 0.1 mg/mL (ultrasonic;warming;heat to 60°C)

• Smiles:

  O=C([C@@H]1CCCO1)NC2=NN=C(N2)CC3=CC(F)=CC=C3

• Molecular Formula:

  C14H15FN4O2

• Molecular Weight:

  290.30

• Precautions:

  H302, H315, H319, H335

• References & Citations:

  [1]Cheng Peng, et al. Mycobacterium tuberculosis suppresses host antimicrobial peptides by dehydrogenating L-alanine. Nat Commun. 2024 May 17;15 (1) :4216.c

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  -20°C, 3 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  [1645486-93-6]