PDMP (hydrochloride)

• Product Name Alternative:

  4'-Fluoro-5'-O-sulfamoyladenosine; NSC 521007

• UNSPSC Description:

  PDMP hydrochloride is a glucosylceramide synthase (GCS) inhibitor. PDMP hydrochloride induces apoptosis in K562/A02 cells. PDMP hydrochloride can be used in cancer (such as leukemia) research[1][2].

• Target Antigen:

  Apoptosis; Glucosylceramide Synthase (GCS)

• Type:

  Reference compound

• Related Pathways:

  Apoptosis;Neuronal Signaling

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/pdmp-hydrochloride.html

• Purity:

  99.0

• Solubility:

  DMSO : 30 mg/mL (ultrasonic;warming)

• Smiles:

  CCCCCCCCCC(NC(CN1CCOCC1)C(C2=CC=CC=C2)O)=O.[x].Cl

• References & Citations:

  [1]Casson L, et al. Inhibition of ceramide metabolism sensitizes human leukemia cells to inhibition of BCL2-like proteins. PLoS One. 2013;8(1):e54525.|[2]Yin L, et al. Effect of PDMP, a glucosylceramide synthase inhibitor, on reversion of daunorubicin resistance in human leukemia cell line K562/A02. Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2010 Feb;18(1):79-84.

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  -20°C (Powder, sealed storage, away from moisture)

• Clinical Information:

  No Development Reported

• CAS Number:

  73257-80-4