Olaptesed pegol

• Description:

  Olaptesed pegol (NOX-A12) L-oligoribonucleotide aptamer targeting CXCL12 based on a pegylated structure. Olaptesed pegol neutralizes CXCL12, and CXCL12 inhibition mobilizes chronic lymphocytic leukemia cells into the circulation and prevents their homing into the protective microenvironment[1].

• UNSPSC:

  12352208

• Target:

  CXCR

• Type:

  Oligonucleotides

• Related Pathways:

  GPCR/G Protein; Immunology/Inflammation

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/olaptesed-pegol.html

• Purity:

  95.94

• Solubility:

  10 mM in DMSO

• Smiles:

  [Olaptesed pegol]

• References & Citations:

  [1]Steurer M, Montillo M, Scarfò L, Mauro FR, Andel J, Wildner S, Trentin L, Janssens A, Burgstaller S, Frömming A, Dümmler T, Riecke K, Baumann M, Beyer D, Vauléon S, Ghia P, Foà R, Caligaris-Cappio F, Gobbi M. Olaptesed pegol (NOX-A12) with bendamustine and rituximab: a phase IIa study in patients with relapsed/refractory chronic lymphocytic leukemia. Haematologica. 2019 Oct;104 (10) :2053-2060.

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  -20°C (Powder, sealed storage, away from moisture)

• Scientific Category:

  Oligonucleotides

• Clinical Information:

  No Development Reported

• CAS Number:

  1390628-22-4