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Rondaptivon pegol

CAT: 0804-HY-153999-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-153999-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Rondaptivon pegol (BT200), a pegylated form of the aptamer BT100, inhibits binding of von Willebrand factor (VWF) to platelet glycoprotein GPIb, preventing arterial thrombosis[1].
CAS Number
2573048-75-4
Product Name Alternative
BT200
UNSPSC
12352208
Target
Integrin
Type
Oligonucleotides
Related Pathways
Cytoskeleton
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/bt200.html
Purity
98.20
Solubility
H2O : ≥ 50 mg/mL
Smiles
[Rondaptivonpegol]
References & Citations
[1]Zhu S, Gilbert JC, Liang Z, et al. Potent and rapid reversal of the von Willebrand factor inhibitor aptamer BT200. J Thromb Haemost. 2020;18 (7) :1695-1704. |[2]Zhu S, Gilbert JC, Hatala P, et al. The development and characterization of a long acting anti-thrombotic von Willebrand factor (VWF) aptamer. J Thromb Haemost. 2020;18 (5) :1113-1123. |[3]Chion A, Byrne C, Atiq F, et al. The aptamer BT200 blocks interaction of K1405-K1408 in the VWF-A1 domain with macrophage LRP1. Blood. 2024;144 (13) :1445-1456.|[4]Ay C, Kovacevic KD, Kraemmer D, et al. The von Willebrand factor-binding aptamer rondaptivon pegol as a treatment for severe and nonsevere hemophilia A. Blood. 2023;141 (10) :1147-1158.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, sealed storage, away from moisture)
Scientific Category
Oligonucleotides
Clinical Information
Phase 2

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