TNF-alpha-IN-1

• UNSPSC Description:

  TNF-alpha-IN-1 (compound 202) is an orally active inhibitor of TNF-alpha. TNF-alpha-IN-1 has anti-inflammatory activity which can used in study rheumatoid arthritis, psoriasis, and asthma[1].

• Target Antigen:

  TNF Receptor

• Type:

  Reference compound

• Related Pathways:

  Apoptosis

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Inflammation/Immunology

• Assay Protocol:

  https://www.medchemexpress.com/tnf-alpha-in-1.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C([C@@H](NC([C@H](NC(CCC(NC1=CC=C(C[C@H](N2)C(N[C@@H](CC3=CC=CC=C3)C(O)=O)=O)C=C1)=O)=O)CCC4=CC=CC=C4)=O)CC5=CC=C(C6=CC=CC=C6)C=C5)C[C@H](CC7=CC=CC=C7)C2=O

• Molecular Weight:

  940.09

• References & Citations:

  [1]Jinbo Lee, et al. Macrocyclic compounds for inhibition of tumor necrosis factor alpha. United States, US8338565B2. 2012-12-25.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported