CG428-NEG

• Description :

  CG428-NEG is a TRK degrader negative control. CG428 (HY-137465) inhibits cell growth and reduce TPM3-TRKA levels[1].

• UNSPSC :

  12352005

• Target :

  PROTACs; Trk Receptor

• Type :

  Reference compound

• Related Pathways :

  Neuronal Signaling; PROTAC; Protein Tyrosine Kinase/RTK

• Field of Research :

  Others

• Assay Protocol :

  https://www.medchemexpress.com/cg428-neg.html

• Purity :

  97.6

• Solubility :

  10 mM in DMSO

• Smiles :

  O=C1N(C(CC2)C(N(C)C2=O)=O)C(C3=C1C=CC=C3NCCOCCC(N4CCN(C5=NC(C6=CN=C7C=CC(N8[C@@H](C9=CC=CC(F)=C9)CCC8)=NN76)=CC=C5)CC4)=O)=O

• Molecular Formula :

  C44H45FN10O6

• Molecular Weight :

  828.89

• References & Citations :

  [1]Chen L, et al. Discovery of First-In-Class Potent and Selective Tropomyosin Receptor Kinase Degraders. J Med Chem. 2020 Dec 10;63 (23) :14562-14575.

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  -20°C, 3 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [2714560-39-9]