CG428-NEG

• Description:

  CG428-NEG is a TRK degrader negative control. CG428 (HY-137465) inhibits cell growth and reduce TPM3-TRKA levels[1].

• UNSPSC:

  12352005

• Target:

  PROTACs; Trk Receptor

• Type:

  Reference compound

• Related Pathways:

  Neuronal Signaling; PROTAC; Protein Tyrosine Kinase/RTK

• Field of Research:

  Others

• Assay Protocol:

  https://www.medchemexpress.com/cg428-neg.html

• Purity:

  97.6

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C1N(C(CC2)C(N(C)C2=O)=O)C(C3=C1C=CC=C3NCCOCCC(N4CCN(C5=NC(C6=CN=C7C=CC(N8[C@@H](C9=CC=CC(F)=C9)CCC8)=NN76)=CC=C5)CC4)=O)=O

• Molecular Formula:

  C44H45FN10O6

• Molecular Weight:

  828.89

• References & Citations:

  [1]Chen L, et al. Discovery of First-In-Class Potent and Selective Tropomyosin Receptor Kinase Degraders. J Med Chem. 2020 Dec 10;63 (23) :14562-14575.

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  -20°C, 3 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  2714560-39-9