CG428-NEG

CG428-NEG

• CAS Number: 2714560-39-9
• UNSPSC Description: CG428-NEG is a TRK degrader negative control. CG428 (HY-137465) inhibits cell growth and reduce TPM3-TRKA levels[1].
• Target Antigen: PROTACs; Trk Receptor
• Type: Reference compound
• Related Pathways: Neuronal Signaling;PROTAC;Protein Tyrosine Kinase/RTK
• Field of Research: Others
• Assay Protocol: https://www.medchemexpress.com/cg428-neg.html
• Solubility: 10 mM in DMSO
• Smiles: O=C1N(C(CC2)C(N(C)C2=O)=O)C(C3=C1C=CC=C3NCCOCCC(N4CCN(C5=NC(C6=CN=C7C=CC(N8[C@@H](C9=CC=CC(F)=C9)CCC8)=NN76)=CC=C5)CC4)=O)=O
• Molecular Weight: 828.89
• References & Citations: [1]Chen L, et al. Discovery of First-In-Class Potent and Selective Tropomyosin Receptor Kinase Degraders. J Med Chem. 2020 Dec 10;63(23):14562-14575.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported