DTAG-47-NEG

• Description :

  DTAG-47-NEG is an analog of dTAG-47 that cannot bind and recruit cereblon (CRBN) . dTAG-47-NEG can be used as a heterobifunctional negative control of dTAG-47[1].

• UNSPSC :

  12352005

• Target :

  PROTACs

• Type :

  Reference compound

• Related Pathways :

  PROTAC

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/dtag-47-neg.html

• Purity :

  97.8

• Solubility :

  DMSO : 106.22 mg/mL (ultrasonic; warming)

• Smiles :

  O=C1N(C2C(NCCC2)=O)C(C3=CC=C(NCCCCCCCCNC(COC4=C(C=CC=C4)[C@@H](CCC5=CC(OC)=C(C=C5)OC)OC([C@H]6N(CCCC6)C([C@H](C7=CC(OC)=C(C(OC)=C7)OC)CC)=O)=O)=O)C=C31)=O

• Molecular Formula :

  C59H75N5O13

• Molecular Weight :

  1062.25

• References & Citations :

  [1]Behnam Nabet, et al. Rapid and direct control of target protein levels with VHL-recruiting dTAG molecules. Nat Commun. 2020 Sep 18;11 (1) :4687.

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  -20°C, 3 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported