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DTAG-47-NEG

CAT: 0804-HY-147099Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-147099Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
DTAG-47-NEG is an analog of dTAG-47 that cannot bind and recruit cereblon (CRBN) . dTAG-47-NEG can be used as a heterobifunctional negative control of dTAG-47[1].
UNSPSC
12352005
Target
PROTACs
Type
Reference compound
Related Pathways
PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/dtag-47-neg.html
Purity
97.8
Solubility
DMSO : 106.22 mg/mL (ultrasonic; warming)
Smiles
O=C1N(C2C(NCCC2)=O)C(C3=CC=C(NCCCCCCCCNC(COC4=C(C=CC=C4)[C@@H](CCC5=CC(OC)=C(C=C5)OC)OC([C@H]6N(CCCC6)C([C@H](C7=CC(OC)=C(C(OC)=C7)OC)CC)=O)=O)=O)C=C31)=O
Molecular Formula
C59H75N5O13
Molecular Weight
1062.25
References & Citations
[1]Behnam Nabet, et al. Rapid and direct control of target protein levels with VHL-recruiting dTAG molecules. Nat Commun. 2020 Sep 18;11 (1) :4687.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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