dTAG-47-NEG

• UNSPSC Description:

  dTAG-47-NEG is an analog of dTAG-47 that cannot bind and recruit cereblon (CRBN). dTAG-47-NEG can be used as a heterobifunctional negative control of dTAG-47[1].

• Target Antigen:

  PROTACs

• Type:

  Reference compound

• Related Pathways:

  PROTAC

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/dtag-47-neg.html

• Purity:

  97.8

• Solubility:

  DMSO : 106.22 mg/mL (ultrasonic;warming)

• Smiles:

  O=C1N(C2C(NCCC2)=O)C(C3=CC=C(NCCCCCCCCNC(COC4=C(C=CC=C4)[C@@H](CCC5=CC(OC)=C(C=C5)OC)OC([C@H]6N(CCCC6)C([C@H](C7=CC(OC)=C(C(OC)=C7)OC)CC)=O)=O)=O)C=C31)=O

• Molecular Weight:

  1062.25

• References & Citations:

  [1]Behnam Nabet, et al. Rapid and direct control of target protein levels with VHL-recruiting dTAG molecules. Nat Commun. 2020 Sep 18;11(1):4687.

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  -20°C, 3 years (Powder)

• Clinical Information:

  No Development Reported