PDEδ autophagic degrader 1

• UNSPSC Description:

  PDEδ autophagic degrader 1 (compound 12c), an autophagosome-tethering compound (ATTEC). is a potent PDEδ autophagic degrader. PDEδ autophagic degrader 1 reduces the PDEδ protein level through lysosome-mediated autophagy without affecting the PDEδ mRNA expression. PDEδ autophagic degrader 1 suppresses the growth in KRAS mutant pancreatic cancer cells[1].

• Target Antigen:

  ATTECs; Autophagy; Phosphodiesterase (PDE)

• Type:

  Reference compound

• Related Pathways:

  Autophagy;Metabolic Enzyme/Protease;PROTAC

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/pdeδ-autophagic-degrader-1.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C(NCCCCCCNC(COC1=C(Br)C=C(/C=C2C(NC3=C\2C=C(I)C=C3)=O)C=C1Br)=O)CCCN4N=C(C)C5=C(C)N(C6=CC=C(C)C=C6)N=C5C4=O

• Molecular Weight:

  999.53

• References & Citations:

  [1]Jingying Bao, et al. Discovery of Novel PDEδ Autophagic Degraders: A Case Study of Autophagy-Tethering Compound (ATTEC). ACS Med Chem Lett. 2023 Dec 29;15(1):29-35.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported