PI3Kα-IN-15

PI3Kα-IN-15

• CAS Number: 2893920-80-2
• UNSPSC Description: PI3Kα-IN-15 is a potent PI3Kα inhibitor with an IC50 of 0.15 μM. PI3Kα-IN-15 also has acceptable anti-proliferative activity (inhibits SKOV-3, T47D, NCI-H1975, NCI-H460, and MCF-7 growth with IC50 values of 26.6 μM, 7.9 μM, 32.1 μM, 17.7 μM, and 9.4 μM, respectively. PI3Kα-IN-15 can be used for cancer research[1].
• Target Antigen: PI3K
• Type: Reference compound
• Related Pathways: PI3K/Akt/mTOR
• Applications: Cancer-Kinase/protease
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/pi3kα-in-15.html
• Solubility: 10 mM in DMSO
• Smiles: O=S(C1=CC=C(F)C=C1)(NC2=CC(C3=CC(C)=CN4C3=NC(C(N5CCCC5)=O)=C4)=CN=C2OC)=O
• Molecular Weight: 509.55
• References & Citations: [1]Rui Chen, et al. Design, synthesis and evaluation of 2, 6, 8-substituted Imidazopyridine derivatives as potent PI3K α inhibitors. J Enzyme Inhib Med Chem. 2023 Dec;38(1):2155638.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported