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Wnt-C59 (GMP)

CAT: 0804-HY-15659GSize: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-15659GSize:1 Each
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Description
Wnt-C59 (C59) GMP is a GMP grade Wnt-C59. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. Wnt-C59 (C59) is a highly potent and oral porcupine (PORCN) inhibitor with an IC50 of 74 pM.
CAS Number
1243243-89-1
Product Name Alternative
C59 (GMP)
UNSPSC
12352005
Hazard Statement
H302-H315-H319-H335
Target
Porcupine; Wnt
Type
GMP Small Molecules
Related Pathways
Stem Cell/Wnt
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/wnt-c59-gmp.html
Solubility
10 mM in DMSO
Smiles
O=C(NC1=CC=C(C2=CC=CN=C2)C=C1)CC3=CC=C(C4=CC(C)=NC=C4)C=C3
Molecular Formula
C25H21N3O
Molecular Weight
379.45
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
References & Citations
[1]Proffitt KD, et al. Pharmacological inhibition of the Wnt acyltransferase PORCN prevents growth of WNT-driven mammary cancer. Cancer Res. 2013 Jan 15;73 (2) :502-7.|[2]Cheng Y, et al. Wnt-C59 arrests stemness and suppresses growth of nasopharyngeal carcinoma in mice by inhibiting the Wnt pathway in the tumor microenvironment. Oncotarget. 2015 Jun 10;6 (16) :14428-39.
Shipping Conditions
Room temperature
Scientific Category
GMP Small Molecules
Clinical Information
No Development Reported

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