Wnt-C59 (Standard)

• Description:

  Wnt-C59 (Standard) is the analytical standard of Wnt-C59. This product is intended for research and analytical applications. Wnt-C59 (C59) is a highly potent and oral porcupine (PORCN) inhibitor with an IC50 of 74 pM.

• UNSPSC:

  12352100

• Hazard Statement:

  H302, H315, H319, H335

• Target:

  Porcupine; Reference Standards; Wnt

• Related Pathways:

  Others; Stem Cell/Wnt

• Field of Research:

  Cancer

• Purity:

  99.80

• Smiles:

  O=C(NC1=CC=C(C2=CC=CN=C2)C=C1)CC3=CC=C(C4=CC(C)=NC=C4)C=C3

• Molecular Formula:

  C25H21N3O

• Molecular Weight:

  379.45

• Precautions:

  H302, H315, H319, H335

• References & Citations:

  [1]Proffitt KD, et al. Pharmacological inhibition of the Wnt acyltransferase PORCN prevents growth of WNT-driven mammary cancer. Cancer Res. 2013 Jan 15;73 (2) :502-7.|[2]Cheng Y, et al. Wnt-C59 arrests stemness and suppresses growth of nasopharyngeal carcinoma in mice by inhibiting the Wnt pathway in the tumor microenvironment. Oncotarget. 2015 Jun 10;6 (16) :14428-39.

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  -20°C, sealed storage, away from light and moisture

• Scientific Category:

  Reference Standards

• CAS Number:

  [1243243-89-1]