SARS-CoV-2-IN-65

SARS-CoV-2-IN-65

• UNSPSC Description: SARS-CoV-2-IN-65 (compound 2f (81)) is a potent,orally active and reversible SARS-CoV-2 entry inhibitor. SARS-CoV-2-IN-65 inhibits the pseudovirus entry in a ACE2-dependent pathway, via mainly inhibiting RBD:ACE2 interaction and TMPRSS2 activity in Calu-3 cells[1].
• Target Antigen: SARS-CoV
• Type: Reference compound
• Related Pathways: Anti-infection
• Applications: COVID-19-anti-virus
• Field of Research: Infection
• Assay Protocol: https://www.medchemexpress.com/sars-cov-2-in-65.html
• Solubility: 10 mM in DMSO
• Smiles: O=C1N(C2=CC=C(C(/C=C/C3=C4C(NC=C4)=CC=C3)=O)C=C2)CC(C(O)=O)C1
• Molecular Weight: 374.39
• References & Citations: [1]Srinivasa Rao Palla, et al. Synthesis, evaluation, and mechanism of 1-(4-(arylethylenylcarbonyl)phenyl)-4-carboxy-2-pyrrolidinones as potent reversible SARS-CoV-2 entry inhibitors. Antiviral Res. 2023 Oct 18:219:105735.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported