SARS-CoV-2-IN-65

• UNSPSC Description:

  SARS-CoV-2-IN-65 (compound 2f (81)) is a potent,orally active and reversible SARS-CoV-2 entry inhibitor. SARS-CoV-2-IN-65 inhibits the pseudovirus entry in a ACE2-dependent pathway, via mainly inhibiting RBD:ACE2 interaction and TMPRSS2 activity in Calu-3 cells[1].

• Target Antigen:

  SARS-CoV

• Type:

  Reference compound

• Related Pathways:

  Anti-infection

• Applications:

  COVID-19-anti-virus

• Field of Research:

  Infection

• Assay Protocol:

  https://www.medchemexpress.com/sars-cov-2-in-65.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C1N(C2=CC=C(C(/C=C/C3=C4C(NC=C4)=CC=C3)=O)C=C2)CC(C(O)=O)C1

• Molecular Weight:

  374.39

• References & Citations:

  [1]Srinivasa Rao Palla, et al. Synthesis, evaluation, and mechanism of 1-(4-(arylethylenylcarbonyl)phenyl)-4-carboxy-2-pyrrolidinones as potent reversible SARS-CoV-2 entry inhibitors. Antiviral Res. 2023 Oct 18:219:105735.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported