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NLRP3-IN-20

CAT: 0804-HY-156121Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-156121Size:1 Each
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Description
NLRP3-IN-20 (compound 11) is an orally available inhibitor of the NLRP3 inflammasome with an IC50 of 25 nM for IL-1β secretion. NLRP3-IN-20 has excellent pharmacokinetic properties and demonstrated significant efficacy in models of non-alcoholic steatohepatitis, fatal septic shock, and colitis[1].
CAS Number
2428478-22-0
UNSPSC
12352005
Target
NOD-like Receptor (NLR)
Type
Reference compound
Related Pathways
Immunology/Inflammation
Applications
COVID-19-immunoregulation
Field of Research
Cancer; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/nlrp3-in-20.html
Solubility
10 mM in DMSO
Smiles
O=S(C1=CC=C(CN(C)C)C=C1)(NC(NC2=C3CCCC3=CC4=C2CCC4)=O)=O
Molecular Formula
C22H27N3O3S
Molecular Weight
413.53
References & Citations
[1]Li Z, et al. Novel Sulfonylurea-Based NLRP3 Inflammasome Inhibitor for Efficient Treatment of Nonalcoholic Steatohepatitis, Endotoxic Shock, and Colitis. J Med Chem. 2023 Sep 11.. .
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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