PDK-IN-2

PDK-IN-2

• CAS Number: 3032446-61-7
• UNSPSC Description: PDK-IN-2 (Compound 1F) is a PDK inhibitor (IC50: 68 nM). PDK-IN-2 inhibits the cellular expression of PDK1 and PDK4. PDK-IN-2 enhances mitochondrial bioenergetics, attenuates glycolytic phenotypes, and induces cell apoptosis in the mitochondrial pathway. PDK-IN-2 inhibits tumor growth in 4T1 syngeneic mice model[1].
• Target Antigen: Mitochondrial Metabolism; PDHK
• Type: Reference compound
• Related Pathways: Metabolic Enzyme/Protease
• Applications: Cancer-Kinase/protease
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/pdk-in-2.html
• Solubility: 10 mM in DMSO
• Smiles: ClC(C(NCCCCCC(NC1=CC=C(C=C1)[As]2SCCCS2)=O)=O)Cl
• Molecular Weight: 497.33
• References & Citations: [1]She W, et al. Reprogramming Energy Metabolism with Synthesized PDK Inhibitors Based on Dichloroacetate Derivatives and Targeted Delivery Systems for Enhanced Cancer Therapy. J Med Chem. 2023 Sep 9.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported