PDK4-IN-2

PDK4-IN-2

• CAS Number: 1616752-12-5
• UNSPSC Description: PDK4-IN-2 (compound 8) is a pyruvate dehydrogenase kinase 4 (PDK4) inhibitor with an IC50 of 46 µM. PDK4-IN-2 improves ejection fraction of failing hearts by regulating bioenergetics via activation of the tricarboxylic acid cycle[1].
• Target Antigen: PDHK
• Type: Reference compound
• Related Pathways: Metabolic Enzyme/Protease
• Applications: Neuroscience-Neuromodulation
• Field of Research: Cardiovascular Disease
• Assay Protocol: https://www.medchemexpress.com/pdk4-in-2.html
• Solubility: 10 mM in DMSO
• Smiles: COC(C1=CC2=C(C(O)=C1)C(C=C(C2=O)C)=O)=O
• Molecular Weight: 246.22
• References & Citations: [1]Kenichi Aizawa, et al. A Potent PDK4 Inhibitor for Treatment of Heart Failure with Reduced Ejection Fraction. Cells. 2023 Dec 30;13(1):87.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported