C-Met-IN-19

CAT: 0804-HY-156098Size: 1 EachDry Ice: NoHazardous: No

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CAT#:0804-HY-156098Size:1 Each

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Description

C-Met-IN-19 (Compound 21j) is a c-Met inhibitor (IC50: 1.99 nM) . c-Met-IN-19 shows cytotoxicity against A549, HT-29, SGC-7901, MDA-MB-231 cells with IC50s of 0.25, 0.36, 0.98, 0.76 μM[1].

UNSPSC

12352005

Target

C-Met/HGFR

Type

Reference compound

Related Pathways

Protein Tyrosine Kinase/RTK

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/c-met-in-19.html

Solubility

10 mM in DMSO

Smiles

COC1=CC2=C(N=CC=C2OC3=CC=C(NC(CCOC)=NS(=O)(CC4=C(Cl)C=CC=C4Cl)=O)C=C3F)C=C1OCCCN5CCOCC5

Molecular Formula

C34H37Cl2FN4O7S

Molecular Weight

735.65

References & Citations

[1]Nan X, et al. Design, synthesis and biological evaluation of sulfonylamidines as potent c-Met inhibitors by enhancing hydrophobic interaction. Org Biomol Chem. 2023 Sep 20;21 (36) :7459-7466.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

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