JMJD3/HDAC-IN-1

JMJD3/HDAC-IN-1

• CAS Number: 2883046-06-6
• UNSPSC Description: JMJD3/HDAC-IN-1 (compound A5b) is a dual inhibitor targeting Jumonji domain-containing protein demethylase 3 (JMJD3) and histone deacetylase (HDAC1, IC50=16 nM). JMJD3/HDAC-IN-1 promotes hypermethylation of histone H3K27 and hyperacetylation of H3K9, and also cleaves caspase-7 and PARP to induce apoptosis. JMJD3/HDAC-IN-1 effectively inhibits cancer cell cloning, migration, and invasion[1].
• Target Antigen: Apoptosis; HDAC; Histone Demethylase
• Type: ADC Related
• Related Pathways: Apoptosis;Cell Cycle/DNA Damage;Epigenetics
• Applications: Cancer-programmed cell death
• Field of Research: cancer
• Assay Protocol: https://www.medchemexpress.com/jmjd3-hdac-in-1.html
• Solubility: 10 mM in DMSO
• Smiles: O=C(CCCCCNC1=NC(C2=NC=CC=C2)=NC(N3CCCCCC3)=C1)NO
• Molecular Weight: 398.50
• References & Citations: [1]Li A, et al. Design, synthesis and biological evaluation of pyrimidine base hydroxamic acid derivatives as dual JMJD3 and HDAC inhibitors. Bioorg Med Chem Lett. 2023 Oct 1;94:129466.. .
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported