CDK9-IN-28

• Description :

  PROTAC CDK9/CycT1 Degrader-1 (compounds 10) is a potent inhibitor of CDK9. PROTAC CDK9/CycT1 Degrader-1 can be used as a PROTAC target protein ligand for PROTAC synthesis. PROTAC CDK9/CycT1 Degrader-1 shows strong anti-proliferative activity in solid tumors[1].

• UNSPSC :

  12352005

• Target :

  CDK

• Type :

  Reference compound

• Related Pathways :

  Cell Cycle/DNA Damage

• Applications :

  Cancer-Kinase/protease

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/protac-cdk9-cyct1-degrader-1.html

• Solubility :

  10 mM in DMSO

• Smiles :

  CC(C)(C1=CN=C(O1)CSC2=CN=C(S2)NC(C3CCN(CC3)CCCCCOC4=C5C(OC(C=C5C)=O)=CC(O)=C4)=O)C

• Molecular Formula :

  C32H40N4O6S2

• Molecular Weight :

  640.81

• References & Citations :

  [1]Zeng Y, et al. Degradation of Cyclin-Dependent Kinase 9/Cyclin T1 by Optimized Microtubule-Associated Protein 1 Light Chain 3 Beta-Recruiting Coumarin Analogs. J Med Chem. 2023 Sep 6.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  CDK9

• CAS Number :

  [3020773-81-0]