EGFR-IN-83

• Description :

  EGFR-IN-83 (Compound 9) is an EGFR inhibitor (IC50: 2.53 nM) . EGFR-IN-83 has antiproliferative activity against MCF-7 and MDA-MB-231 cells, with IC50 of 2.50 μM and 1.96 μM. EGFR-IN-83 can induce cell apoptosis[1].

• UNSPSC :

  12352005

• Target :

  Apoptosis; EGFR

• Type :

  Reference compound

• Related Pathways :

  Apoptosis; JAK/STAT Signaling; Protein Tyrosine Kinase/RTK

• Applications :

  Cancer-Kinase/protease

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/egfr-in-83.html

• Solubility :

  10 mM in DMSO

• Smiles :

  OCC1=CC=C(NC2=CC3=NC=NC(NC4=CC=CC(C(F)(F)F)=C4)=C3C=C2)C=C1

• Molecular Formula :

  C22H17F3N4O

• Molecular Weight :

  410.39

• References & Citations :

  [1]Hossam Nada, et al. Machine Learning-Based Approach to Developing Potent EGFR Inhibitors for Breast Cancer-Design, Synthesis, and In Vitro Evaluation. ACS Omega 2023, 8, 35, 31784-31800.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported