Antidiabetic agent 2

• Description:

  Antidiabetic agent 2 (Compound 56) is a glucose-uptake promoter. Antidiabetic agent 2 inhibits DPP-4, PTP-1B, α-amylase, and α-glucosidase with IC50s of 0.036, 0.042, 0.241, 0.185 μM. Antidiabetic agent 2 decreases blood glucose levels[1].

• UNSPSC:

  12352005

• Target:

  Amylases; Dipeptidyl Peptidase; Glycosidase; Phosphatase

• Type:

  Reference compound

• Related Pathways:

  Metabolic Enzyme/Protease

• Applications:

  Metabolism-sugar/lipid metabolism

• Field of Research:

  Metabolic Disease

• Assay Protocol:

  https://www.medchemexpress.com/antidiabetic-agent-2.html

• Solubility:

  10 mM in DMSO

• Smiles:

  OC1=CC(C(NC2=CC=C(C=C2)/C=C(C(N3C(CN(CC4=N5)CC4=CN5S(C)(=O)=O)=O)=O)\SC3=O)=O)=CC(O)=C1O

• Molecular Formula:

  C25H21N5O9S2

• Molecular Weight:

  599.59

• References & Citations:

  [1]Shah M, et al. SAR and lead optimization of (Z) -5- (4-hydroxy-3-methoxybenzylidene) -3- (2-morpholinoacetyl) thiazolidine-2,4-dione as a potential multi-target antidiabetic agent. Eur J Med Chem. 2023 Oct 5;258:115591.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  [3052242-32-4]