Phen-DC3

• Description :

  Phen-DC3 is a G-quadruplex (G4) specific ligand which can inhibit FANCJ and DinG helicases with IC50s of 65±6 and 50±10 nM, respectively.

• UNSPSC :

  12352005

• Target :

  DNA/RNA Synthesis

• Type :

  Reference compound

• Related Pathways :

  Cell Cycle/DNA Damage

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/Phen-DC3.html

• Solubility :

  DMSO : ≥ 34 mg/mL

• Smiles :

  C[N+]1=C2C=CC=CC2=CC(NC(C3=CC=C4C=CC5=CC=C(C(NC6=C[N+](C)=C7C=CC=CC7=C6)=O)N=C5C4=N3)=O)=C1

• Molecular Formula :

  C34H26N6O2

• Molecular Weight :

  550.61

• References & Citations :

  [1]Bharti SK, et al. Specialization among iron-sulfur cluster helicases to resolve G-quadruplex DNA structures that threaten genomic stability. J Biol Chem. 2013 Sep 27; 288 (39) :28217-29.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Citation 01 :

  J Phys Chem B. 2023 Jul 6;127 (26) :5859-5868.|Nucleic Acids Res. 2024 Mar 21;52 (5) :2142-2156.|Patent. US20210188889A1.|Cell Death Dis. 2021 Oct 25;12 (11) :999.|Int J Biol Macromol. 2025 Jan 9:139582.|Int J Biol Macromol. 2025 Jun 20;319 (Pt 1) :145405.|iScience. 2022 Oct 9;25 (11) :105312.

• CAS Number :

  [942936-75-6]