Phen-DC3

• Description:

  Phen-DC3 is a G-quadruplex (G4) specific ligand which can inhibit FANCJ and DinG helicases with IC50s of 65±6 and 50±10 nM, respectively.

• UNSPSC:

  12352005

• Target:

  DNA/RNA Synthesis

• Type:

  Reference compound

• Related Pathways:

  Cell Cycle/DNA Damage

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/Phen-DC3.html

• Solubility:

  DMSO : ≥ 34 mg/mL

• Smiles:

  C[N+]1=C2C=CC=CC2=CC (NC (C3=CC=C4C=CC5=CC=C (C (NC6=C[N+] (C) =C7C=CC=CC7=C6) =O) N=C5C4=N3) =O) =C1

• Molecular Formula:

  C34H26N6O2

• Molecular Weight:

  550.61

• References & Citations:

  [1]Bharti SK, et al. Specialization among iron-sulfur cluster helicases to resolve G-quadruplex DNA structures that threaten genomic stability. J Biol Chem. 2013 Sep 27; 288 (39) :28217-29.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Citation 01:

  J Phys Chem B. 2023 Jul 6;127 (26) :5859-5868.|Nucleic Acids Res. 2024 Mar 21;52 (5) :2142-2156.|Patent. US20210188889A1.|Cell Death Dis. 2021 Oct 25;12 (11) :999.|Int J Biol Macromol. 2025 Jan 9:139582.|Int J Biol Macromol. 2025 Jun 20;319 (Pt 1) :145405.|iScience. 2022 Oct 9;25 (11) :105312.

• CAS Number:

  942936-75-6