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BpV (phen)

CAT: 804-HY-136065-01Size: 5 mgDry Ice: NoHazardous: No
5 mgSelected
PRICE
AVAILABILITY
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
BpV (phen), a insulin-mimetic agent, is a potent protein tyrosine phosphatase (PTP) and PTEN inhibitor with IC50s of 38 nM, 343 nM and 920 nM for PTEN, PTP-β and PTP-1B, respectively. bpV (phen) inhibits proliferation of the protozoan parasite Leishmania in vitro. bpV (phen) strongly induces the secretion of a large number of chemokines and pro-inflammatory cytokines, and it activates a Th1-type pathway (IL-12, IFNγ) . bpV (phen) can also induce cell apoptosis, and has anti-angiogenic and anti-tumor activity[1][2][3][4][5].
CAS Number
[42494-73-5]
UNSPSC
12352005
Hazard Statement
H315, H319, H335
Target
Apoptosis; Parasite; Phosphatase; PTEN
Type
Reference compound
Related Pathways
Anti-infection; Apoptosis; Metabolic Enzyme/Protease; PI3K/Akt/mTOR
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Cancer; Infection; Metabolic Disease; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/bpv-phen.html
Purity
98.0
Solubility
10 mM in DMSO
Smiles
O=[V+3]12([N]3=CC=C4)([O-][O-]1)([O-][O-]2)[N]5=C6C3=C4C=CC6=CC=C5.[K+]
Molecular Formula
C12H8KN2O5V
Molecular Weight
350.24
Precautions
H315, H319, H335
References & Citations
[1]Tang W, et al. PTEN-mediated mitophagy and APE1 overexpression protects against cardiac hypoxia/reoxygenation injury. In Vitro Cell Dev Biol Anim. 2019 Oct;55 (9) :741-748.|[2]Caron D, et al. Protein tyrosine phosphatase inhibition induces anti-tumor activity: evidence of Cdk2/p27 kip1 and Cdk2/SHP-1 complex formation in human ovarian cancer cells. Cancer Lett. 2008 Apr 18;262 (2) :265-75.|[3]Schmid AC, et al. Bisperoxovanadium compounds are potent PTEN inhibitors. FEBS Lett. 2004 May 21;566 (1-3) :35-8.|[4] Band CJ, et al. Early signaling events triggered by peroxovanadium [bpV (phen) ] are insulin receptor kinase (IRK) -dependent: specificity of inhibition of IRK-associated protein tyrosine phosphatase (s) by bpV (phen) . Mol Endocrinol. 1997 Dec;11 (13) :1899-910.|[5]Chen Q, et al. Potassium Bisperoxo (1,10-phenanthroline) oxovanadate (bpV (phen) ) Induces Apoptosis and Pyroptosis and Disrupts the P62-HDAC6 Protein Interaction to Suppress the Acetylated Microtubule-dependent Degradation of Autophagosomes. J Biol Chem. 2015 Oct 23;290 (43) :26051-8.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Leishmania
Citation 01
Biochem Bioph Res Co. 2020 Sep 3;529 (4) :1045-1052.|Nat Commun. 2022 May 19;13 (1) :2762.

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