BpV (phen)

• Description:

  BpV (phen), a insulin-mimetic agent, is a potent protein tyrosine phosphatase (PTP) and PTEN inhibitor with IC50s of 38 nM, 343 nM and 920 nM for PTEN, PTP-β and PTP-1B, respectively. bpV (phen) inhibits proliferation of the protozoan parasite Leishmania in vitro. bpV (phen) strongly induces the secretion of a large number of chemokines and pro-inflammatory cytokines, and it activates a Th1-type pathway (IL-12, IFNγ) . bpV (phen) can also induce cell apoptosis, and has anti-angiogenic and anti-tumor activity[1][2][3][4][5].

• UNSPSC:

  12352005

• Hazard Statement:

  H315, H319, H335

• Target:

  Apoptosis; Parasite; Phosphatase; PTEN

• Type:

  Reference compound

• Related Pathways:

  Anti-infection; Apoptosis; Metabolic Enzyme/Protease; PI3K/Akt/mTOR

• Applications:

  Metabolism-sugar/lipid metabolism

• Field of Research:

  Cancer; Infection; Metabolic Disease; Inflammation/Immunology

• Assay Protocol:

  https://www.medchemexpress.com/bpv-phen.html

• Purity:

  98.0

• Solubility:

  10 mM in DMSO

• Smiles:

  O=[V+3]12([N]3=CC=C4)([O-][O-]1)([O-][O-]2)[N]5=C6C3=C4C=CC6=CC=C5.[K+]

• Molecular Formula:

  C12H8KN2O5V

• Molecular Weight:

  350.24

• Precautions:

  H315, H319, H335

• References & Citations:

  [1]Tang W, et al. PTEN-mediated mitophagy and APE1 overexpression protects against cardiac hypoxia/reoxygenation injury. In Vitro Cell Dev Biol Anim. 2019 Oct;55 (9) :741-748.|[2]Caron D, et al. Protein tyrosine phosphatase inhibition induces anti-tumor activity: evidence of Cdk2/p27 kip1 and Cdk2/SHP-1 complex formation in human ovarian cancer cells. Cancer Lett. 2008 Apr 18;262 (2) :265-75.|[3]Schmid AC, et al. Bisperoxovanadium compounds are potent PTEN inhibitors. FEBS Lett. 2004 May 21;566 (1-3) :35-8.|[4] Band CJ, et al. Early signaling events triggered by peroxovanadium [bpV (phen) ] are insulin receptor kinase (IRK) -dependent: specificity of inhibition of IRK-associated protein tyrosine phosphatase (s) by bpV (phen) . Mol Endocrinol. 1997 Dec;11 (13) :1899-910.|[5]Chen Q, et al. Potassium Bisperoxo (1,10-phenanthroline) oxovanadate (bpV (phen) ) Induces Apoptosis and Pyroptosis and Disrupts the P62-HDAC6 Protein Interaction to Suppress the Acetylated Microtubule-dependent Degradation of Autophagosomes. J Biol Chem. 2015 Oct 23;290 (43) :26051-8.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  4°C (Powder, sealed storage, away from moisture)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  Leishmania

• Citation 01:

  Biochem Bioph Res Co. 2020 Sep 3;529 (4) :1045-1052.|Nat Commun. 2022 May 19;13 (1) :2762.

• CAS Number:

  [42494-73-5]