Lepadin E

• Description:

  Lepadin E is a significantly cytotoxic ferroptosis inducer that induces iron death through the classical p53-SLC7A11-GPX4 pathway. Lepadin E promoted p53 expression, decreases SLC7A11 and GPX4 levels, and leads to increased ROS and lipid peroxide production, and upregulated ACSL4 expression, thus causes cell death. Lepadin E has significant antitumor effect[1].

• UNSPSC:

  12352005

• Target:

  Ferroptosis; Glutathione Peroxidase; MDM-2/p53

• Type:

  Natural Products

• Related Pathways:

  Apoptosis; Metabolic Enzyme/Protease

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/lepadin-e.html

• Solubility:

  10 mM in DMSO

• Smiles:

  CCC[C@H](CCCC[C@@H](CCC[C@@]12[H])[C@]2([H])C[C@H]([C@@H](N1)C)OC(/C=C/CCCCC)=O)O

• Molecular Formula:

  C26H47NO3

• Molecular Weight:

  421.66

• References & Citations:

  [1]Wang W, et al. Marine Alkaloid Lepadins E and H Induce Ferroptosis for Cancer Chemotherapy. J Med Chem. 2023 Aug 24;66 (16) :11201-11215.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Natural Products

• Clinical Information:

  No Development Reported

• CAS Number:

  [444914-19-6]