Lepadin H

• Description:

  Lepadin H is a marine alkaloid and ferroptosis inducer. Lepadin H exhibits significant cytotoxicity, promotes p53 expression, increases ROS production and lipid peroxidation, decreases SLC7A11 and GPX4 levels, and upregulates ACSL4 expression. Lepadin H induces ferroptosis through the p53-SLC7A11-GPX4 pathway[1].

• UNSPSC:

  12352005

• Target:

  Ferroptosis

• Type:

  Natural Products

• Related Pathways:

  Apoptosis

• Field of Research:

  Others

• Assay Protocol:

  https://www.medchemexpress.com/lepadin-h.html

• Solubility:

  10 mM in DMSO

• Smiles:

  CCC[C@@H](O)CCCC[C@@H]1[C@@]2([H])[C@](CCC1)([H])N[C@H]([C@@H](C2)OC(/C=C/C=C/CCC)=O)C

• Molecular Formula:

  C26H45NO3

• Molecular Weight:

  419.64

• References & Citations:

  [1]Wang W, et al. Marine Alkaloid Lepadins E and H Induce Ferroptosis for Cancer Chemotherapy. J Med Chem. 2023 Aug 24;66 (16) :11201-11215.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Natural Products

• Clinical Information:

  No Development Reported

• CAS Number:

  412328-25-7