Lepadin H

• Target:

  Ferroptosis

• Related Pathways:

  Apoptosis

• Bioactivity:

  Lepadin H, a marine alkaloid and ferroptosis inducer, exhibits significant cytotoxicity by promoting p53 expression, escalating ROS production, and enhancing lipid peroxidation. It simultaneously decreases SLC7A11 and GPX4 levels while upregulating ACSL4 expression, thereby inducing ferroptosis via the p53-SLC7A11-GPX4 pathway [1].

• Smiles:

  C(CCC[C@@H](CCC)O)[C@@H]1[C@]2([C@](N[C@@H](C)[C@H](OC(/C=C/C=C/CCC)=O)C2)(CCC1)[H])[H]

• Molecular Formula:

  C26H45NO3

• Molecular Weight:

  419.64

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  412328-25-7