Auristatin E (GMP)

• Description :

  Auristatin E (GMP) is Auristatin E (HY-15582) produced by using GMP guidelines. Auristatin E is a tubulin polymerization inhibitor[1].

• CAS Number :

  [160800-57-7]

• UNSPSC :

  12352005

• Hazard Statement :

  H341-H361-H372

• Target :

  ADC Payload; Microtubule/Tubulin

• Type :

  GMP Small Molecules

• Related Pathways :

  Antibody-drug Conjugate/ADC Related; Cell Cycle/DNA Damage; Cytoskeleton

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/auristatin-e-gmp.html

• Solubility :

  10 mM in DMSO

• Smiles :

  CC(C)[C@H](N(C)C)C(N[C@H](C(N([C@@H]([C@@H](C)CC)[C@@H](CC(N1CCC[C@@]1([H])[C@H](OC)[C@@H](C)C(N[C@H](C)[C@H](C2=CC=CC=C2)O)=O)=O)OC)C)=O)C(C)C)=O

• Molecular Formula :

  C40H69N5O7

• Molecular Weight :

  732.01

• Precautions :

  P260-P264-P270-P280-P405-P501

• References & Citations :

  [1]Francisco JA, et al. cAC10-vcMMAE, an anti-CD30-monomethyl auristatin E conjugate with potent and selective antitumor activity. Blood. 2003 Aug 15;102 (4) :1458-65.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  GMP Small Molecules

• Clinical Information :

  No Development Reported