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Monomethyl auristatin E

CAT: 0804-HY-15162-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-15162-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Monomethyl auristatin E (MMAE; SGD-1010) is a synthetic derivative of dolastatin 10 and functions as a potent mitotic inhibitor by inhibiting tubulin polymerization. MMAE is widely used as a cytotoxic component of antibody-drug conjugates (ADCs) to treat several different cancer types.
CAS Number
474645-27-7
Product Name Alternative
MMAE; SGD-1010
UNSPSC
12352203
Hazard Statement
H300+H330, H340, H360, H370, H372, H412
Target
ADC Payload; Apoptosis; Microtubule/Tubulin
Type
ADC Related
Related Pathways
Antibody-drug Conjugate/ADC Related; Apoptosis; Cell Cycle/DNA Damage; Cytoskeleton
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/Monomethyl-auristatin-E.html
Purity
99.98
Solubility
DMSO : ≥ 48 mg/mL|Ethanol : 50 mg/mL (ultrasonic) |H2O : < 0.1 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
CC(C)[C@H](NC)C(N[C@@H](C(C)C)C(N(C)[C@H]([C@@H](CC(N1[C@]([C@H](OC)[C@H](C(N[C@@H]([C@H](C2=CC=CC=C2)O)C)=O)C)(CCC1)[H])=O)OC)[C@H](CC)C)=O)=O
Molecular Formula
C39H67N5O7
Molecular Weight
717.98
Precautions
H300+H330, H340, H360, H370, H372, H412
References & Citations
[1]Okeley, et al. Intracellular Activation of SGN-35, a Potent Anti-CD30 Antibody-Drug Conjugate. Clinical Cancer Research (2010), 16 (3), 888-897.|[2]Lisa Buckel, et al. Tumor radiosensitization by monomethyl auristatin E: mechanism of action and targeted delivery. Cancer Res. 2015 Apr 1;75 (7) :1376-87.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, sealed storage, away from moisture and light)
Scientific Category
ADC Related
Clinical Information
Phase 4
Isoform
Auristatin

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