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DPP9-IN-2

CAT: 0804-HY-179348Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-179348Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
DPP9-IN-2 is a selective, potent and orally active inhibitor of Dipeptidyl Peptidase 9 (DPP9) with an IC50 of 12.9 nM. DPP9-IN-2 shows a SI of 59 over DPP8, and shows no significant inhibitory activity against related peptidases including DPP2, DPP4, FAP, and PREP. DPP9-IN-2 can induce cancer cells pyroptosis and has weak synergistic anti-HIV-1 activity when combined with non-nucleoside reverse transcriptase inhibitor. DPP9-IN-2 can be used for the researches of cance rand infection[1].
CAS Number
[3020859-44-0]
UNSPSC
12352005
Target
Dipeptidyl Peptidase; HIV; Pyroptosis
Related Pathways
Anti-infection; Apoptosis; Immunology/Inflammation; Metabolic Enzyme/Protease
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Smiles
O=C(C1=CC=C(C2=CC=C(F)C=C2)C=C1)NC34CC5(NCC(N6CC7=C(C=C(F)C=C7)C6)=O)CC(C4)CC(C5)C3
Molecular Formula
C33H33F2N3O2
Molecular Weight
541.63
References & Citations
[1]Filippi N, et al. Selective and Orally Bioavailable Dipeptidyl Peptidase 9 Inhibitors with Potent Pyroptosis Induction Properties. J Med Chem. 2025;68 (21) :23163-23184.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
DPP-9; HIV-1

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