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SPC-180002

CAT: 0804-HY-155784Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-155784Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
SPC-180002 is a SIRT1/3 dual inhibitor, with IC50 values of 1.13 and 5.41 μM, respectively. SPC-180002 disturbs redox homeostasis via ROS generation, which leads to an increase in both p21 protein stability and mitochondrial dysfunction. SPC-180002 strongly inhibits cell cycle progression and cancer cell growth. SPC-180002 activates the Nrf2 signaling pathway[1].
CAS Number
2170274-53-8
UNSPSC
12352005
Target
Keap1-Nrf2; Reactive Oxygen Species (ROS) ; Sirtuin
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Epigenetics; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/spc-180002.html
Solubility
10 mM in DMSO
Smiles
O=C(C(CN(CCC1=CC=CC=C1)CC(C(OC)=O)=C)=C)OC
Molecular Formula
C18H23NO4
Molecular Weight
317.38
References & Citations
[1]Cho Y, et al. SPC-180002, a SIRT1/3 dual inhibitor, impairs mitochondrial function and redox homeostasis and represents an antitumor activity. Free Radic Biol Med. 2023 Aug 2;208:73-87.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
SIRT1; SIRT3

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