SPC-180002

• UNSPSC Description:

  SPC-180002 is a SIRT1/3 dual inhibitor, with IC50 values of 1.13 and 5.41 μM, respectively. SPC-180002 disturbs redox homeostasis via ROS generation, which leads to an increase in both p21 protein stability and mitochondrial dysfunction. SPC-180002 strongly inhibits cell cycle progression and cancer cell growth. SPC-180002 activates the Nrf2 signaling pathway[1].

• Target Antigen:

  Keap1-Nrf2; Reactive Oxygen Species; Sirtuin

• Type:

  Reference compound

• Related Pathways:

  Cell Cycle/DNA Damage;Epigenetics;Immunology/Inflammation;Metabolic Enzyme/Protease;NF-κB

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/spc-180002.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C(C(CN(CCC1=CC=CC=C1)CC(C(OC)=O)=C)=C)OC

• Molecular Weight:

  317.38

• References & Citations:

  [1]Cho Y, et al. SPC-180002, a SIRT1/3 dual inhibitor, impairs mitochondrial function and redox homeostasis and represents an antitumor activity. Free Radic Biol Med. 2023 Aug 2;208:73-87.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  2170274-53-8