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FR 180204

CAT: 0804-HY-12275-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-12275-01Size:5 mg
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Description
FR 180204 is an ATP-competitive and selective ERK inhibitor. FR 180204 inhibits ERK1 and ERK2 with IC50s of 0.51 μM (Ki=0.31 μM) and 0.33 μM (Ki=0.14 μM), respectively[1].
CAS Number
865362-74-9
UNSPSC
12352005
Hazard Statement
H302
Target
Apoptosis; Dengue Virus; ERK; Flavivirus
Type
Reference compound
Related Pathways
Anti-infection; Apoptosis; MAPK/ERK Pathway; Stem Cell/Wnt
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/FR-180204.html
Purity
99.91
Solubility
DMSO : ≥ 50 mg/mL
Smiles
NC1=NNC2=NN=C(C3=C4C=CC=CN4N=C3C5=CC=CC=C5)C=C21
Molecular Formula
C18H13N7
Molecular Weight
327.34
Precautions
H302
References & Citations
[1]Ohori M, et al. Identification of a selective ERK inhibitor and structural determination of the inhibitor-ERK2 complex. Biochem Biophys Res Commun. 2005 Oct 14;336 (1) :357-63.|[2]Ohori M, et al. FR180204, a novel and selective inhibitor of extracellular signal-regulated kinase, ameliorates collagen-induced arthritis in mice. Naunyn Schmiedebergs Arch Pharmacol. 2007 Jan;374 (4) :311-6.|[3]Honda M, et al. Mesothelioma cell proliferation through autocrine activation of PDGF-ββ receptor. Cell Physiol Biochem. 2012;29 (5-6) :667-74|[4]Sreekanth GP, et al. Role of ERK1/2 signaling in dengue virus-induced liver injury. Virus Res. 2014 Aug 8;188:15-26
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
ERK1; ERK2

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