AChE/Aβ-IN-2

CAT: 0804-HY-155735Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-155735Size:1 Each
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Description
AChE/Aβ-IN-2 (compound 33) is a potent and orally active inhibitor of acetylcholinesterase (AChE) with IC50 of 135 nM, as well as an antagonist of NMDA receptor (GluN1-1b/GluN2B subunit combination) with IC50 of 5.054 μM. AChE/Aβ-IN-2 also inhibits Aβ aggregation and shows good blood-brain barrier permeability. AChE/Aβ-IN-2 improves cognitive and spatial memory impairment in rats model[1].
UNSPSC
12352005
Target
Amyloid-β; Cholinesterase (ChE) ; iGluR
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/ache-aβ-in-2.html
Solubility
10 mM in DMSO
Smiles
ClC1=CC=C(C=C1)CN2C=C(N=N2)CNC34CC(C5)CC(C4)CC5C3
Molecular Formula
C20H25ClN4
Molecular Weight
356.89
References & Citations
[1]Gutti G, et al. Discovery of triazole-bridged aryl adamantane analogs as an intriguing class of multifunctional agents for treatment of Alzheimer's disease. Eur J Med Chem. 2023 Nov 5;259:115670.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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