AChE/Aβ-IN-2

AChE/Aβ-IN-2

• UNSPSC Description: AChE/Aβ-IN-2 (compound 33) is a potent and orally active inhibitor of acetylcholinesterase (AChE) with IC50 of 135 nM, as well as an antagonist of NMDA receptor (GluN1-1b/GluN2B subunit combination) with IC50 of 5.054 μM. AChE/Aβ-IN-2 also inhibits Aβ aggregation and shows good blood-brain barrier permeability. AChE/Aβ-IN-2 improves cognitive and spatial memory impairment in rats model[1].
• Target Antigen: Amyloid-β; Cholinesterase (ChE); iGluR
• Type: Reference compound
• Related Pathways: Membrane Transporter/Ion Channel;Neuronal Signaling
• Applications: Neuroscience-Neurodegeneration
• Field of Research: Neurological Disease
• Assay Protocol: https://www.medchemexpress.com/ache-aβ-in-2.html
• Solubility: 10 mM in DMSO
• Smiles: ClC1=CC=C(C=C1)CN2C=C(N=N2)CNC34CC(C5)CC(C4)CC5C3
• Molecular Weight: 356.89
• References & Citations: [1]Gutti G, et al. Discovery of triazole-bridged aryl adamantane analogs as an intriguing class of multifunctional agents for treatment of Alzheimer's disease. Eur J Med Chem. 2023 Nov 5;259:115670.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported