BMP agonist 1

• Description :

  BMP agonist 1 (compound 2 b) is a small-molecule agonist of bone morphogenic protein (BMP) . BMP induces C2C12 cell differentiation with BMP and highly depends on active BMP signaling. BMP agonist 1 inhibits GSK3β, increases β-catenin signaling and synergistically regulates Id2and Id3 expression. BMP agonist 1 is used in diseases and defects of the skeleton research[1].

• UNSPSC :

  12352005

• Target :

  GSK-3; TGF-β Receptor; β-catenin

• Type :

  Reference compound

• Related Pathways :

  PI3K/Akt/mTOR; Stem Cell/Wnt; TGF-beta/Smad

• Applications :

  Cancer-Kinase/protease

• Field of Research :

  Others

• Assay Protocol :

  https://www.medchemexpress.com/bmp-agonist-1.html

• Solubility :

  10 mM in DMSO

• Smiles :

  OC1=CC2=C(C=C1)NC3=C2C(C(N4)=O)=C(C5=CC(OC)=C(C(OC)=C53)OC)C4=O

• Molecular Formula :

  C21H16N2O6

• Molecular Weight :

  392.36

• References & Citations :

  [1]Riege D, et al. Identification of Maleimide-Fused Carbazoles as Novel Noncanonical Bone Morphogenetic Protein Synergizers. ACS Pharmacol Transl Sci. 2023 Jul 19;6 (8) :1207-1220.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported