HBpep-SA

• UNSPSC Description:

  HBpep-SA is a cell membrane-permeable peptide condensate that phase separates to form stable droplets at pH values below 6.5. HBpep-SA is able to directly and efficiently deliver a variety of macromolecules, ranging from therapeutic peptides as small as 726 Da to large enzymes as large as 430 kDa, and the loaded condensates remain stable under near-physiological and serum conditions until internalized by cells. HBpep-SA can be used for intracellular delivery of large numbers of macromolecules and as a vector for mRNA-based vaccines[1].

• Target Antigen:

  Others

• Type:

  Peptides

• Related Pathways:

  Others

• Field of Research:

  Others

• Assay Protocol:

  https://www.medchemexpress.com/hbpep-sa.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C(OCCSSCCOC(C)=O)NCCCC[C@H](NC([C@@H](NC([C@H]1N(CCC1)C(CNC([C@@H](NC(CNC([C@@H](NC([C@@H](NC(CNC([C@@H](NC(CNC([C@@H](NC([C@@H](NC(CNC([C@@H](NC(CN)=O)CC2=CNC=N2)=O)=O)C(C)C)=O)CC3=CC=C(O)C=C3)=O)=O)CC4=CNC=N4)=O)=O)C(C)C)=O)CC5=CC=C(O)C=C5)=O)=O)CC6=CNC=N6)=O)=O)=O)CC7=CC=C(O)C=C7)=O)C(NCC(N[C@H](C(NCC(N8[C@H](C(N[C@H](C(NCC(N[C@H](C(NCC(N[C@H](C(N[C@H](C(N[C@H](C(O)=O)CC9=CNC%10=CC=CC=C9%10)=O)CC%11=CC=C(O)C=C%11)=O)CC(C)C)=O)=O)CC%12=CNC=N%12)=O)=O)CC%13=CC=C(O)C=C%13)=O)CCC8)=O)=O)CC%14=CNC=N%14)=O)=O

• Molecular Weight:

  3132.41

• References & Citations:

  [1]Sun Y, et al. Phase-separating peptides for direct cytosolic delivery and redox-activated release of macromolecular therapeutics. Nat Chem. 2022 Mar;14(3):274-283.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported