SARS-CoV-2 nsp14-IN-4

SARS-CoV-2 nsp14-IN-4

• UNSPSC Description: SARS-CoV-2 nsp14-IN-4 (Compound 12q) is an inhibitor of SARS-CoV-2 nsp14 methyltransferase (IC50=19 nM). SARS-CoV-2 nsp14-IN-4 is non-cytotoxic and cell-permeable. SARS-CoV-2 nsp14-IN-4 is used in COVID-19 research[1].
• Target Antigen: SARS-CoV
• Type: Reference compound
• Related Pathways: Anti-infection
• Applications: COVID-19-anti-virus
• Field of Research: Infection
• Assay Protocol: https://www.medchemexpress.com/sars-cov-2-nsp14-in-4.html
• Solubility: 10 mM in DMSO
• Smiles: O[C@H]1[C@@H](O)[C@H](N2C=C(C#CC3=CC4=CC=CC=C4N=C3)C(C2=NC=N5)=C5N)O[C@@H]1CN(C)S(C6=CC=C(OC)C(C#N)=C6)(=O)=O
• Molecular Weight: 625.65
• References & Citations: [1]Štefek M, et al. Rational Design of Highly Potent SARS-CoV-2 nsp14 Methyltransferase Inhibitors. ACS Omega. 2023 Jul 21;8(30):27410-27418.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported