SARS-CoV-2 nsp14-IN-1

SARS-CoV-2 nsp14-IN-1

• CAS Number: 2816165-02-1
• UNSPSC Description: SARS-CoV-2 nsp14-IN-1 (Compound 3) is a prototypic bisubstrate inhibitor of SARS-CoV-2 Nsp14 MTase with an IC50 value of 0.061 μM. SARS-CoV-2 nsp14-IN-1 (Compound 3) has an excellent selectivity profile over a panel of human methyltransferases, can against apanel of 10 human MTases including histone lysine, proteinarginine, and DNA and RNA MTases[1].
• Target Antigen: DNA Methyltransferase; Histone Methyltransferase; SARS-CoV
• Type: Reference compound
• Related Pathways: Anti-infection;Epigenetics
• Applications: COVID-19-anti-virus
• Field of Research: Infection
• Assay Protocol: https://www.medchemexpress.com/sars-cov-2-nsp14-in-1.html
• Solubility: 10 mM in DMSO
• Smiles: O=S(C1=CC=C2C=CC=CC2=C1)(NC[C@H]3O[C@@H](N4C=NC5=C(N)N=CN=C45)[C@H](O)[C@@H]3O)=O
• Molecular Weight: 456.48
• References & Citations: [1]Eunkyung Jung, et al. Bisubstate Inhibitors of Severe Acute Respiratory Syndrome Coronavirus-2 Nsp14 Methyltransferase. ACS Med. Chem. Lett. July 22, 2022.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported