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JNK-1-IN-2

CAT: 0804-HY-155593Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-155593Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
JNK-1-IN-2 (Compound c6) is a JNK-1 inhibitor (IC50: 33.5 nM) . JNK-1-IN-2 also inhibits JNK-2 and JNK-3 with IC50s of 112.9 nM and 33.2 nM. JNK-1-IN-2 inhibits the phosphorylation of c-Jun. JNK-1-IN-2 reverses lung impairment. JNK-1-IN-2 can be used for research of pulmonary fibrosis[1].
UNSPSC
12352005
Target
JNK
Type
Reference compound
Related Pathways
MAPK/ERK Pathway
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/jnk-1-in-2.html
Solubility
10 mM in DMSO
Smiles
O=C(N)C1=CC=CC=C1NC2=NC(NCC(C)(C)C)=NC=C2Br
Molecular Formula
C16H20BrN5O
Molecular Weight
378.27
References & Citations
[1]Qian H, et al. Synthesis-accessibility-oriented design of c-Jun N-terminal kinase 1 inhibitor. Eur J Med Chem. 2023 Aug 5;256:115442.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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