JNK-1-IN-4

CAT: 0931-T200667-01Size: 25 mgDry Ice: NoHazardous: No

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CAT#:0931-T200667-01Size:25 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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CAS Number

3047795-60-5

Target

JNK

Related Pathways

MAPK

Bioactivity

JNK-1-IN-4 (Compound E1) is an inhibitor of JNK, targeting JNK-1, JNK-2, and JNK-3 with IC50 values of 2.7, 19.0, and 9.0 nM, respectively. This compound inhibits the phosphorylation of c-Jun and reduces the expression of TGF-β1-induced EMT markers (such as fibronectin and α-SMA) . JNK-1-IN-4 exhibits favorable pharmacokinetic properties with a bioavailability of 69%. Additionally, it demonstrates antifibrotic effects in a Bleomycin-induced mouse model of idiopathic pulmonary fibrosis.

Smiles

O=C(N)C1=CC(OCCN(C)C)=CC=C1NC2=NC(=NC=C2Br)NC3=CC=C(OC)C=C3

Molecular Formula

C22H25BrN6O3

Molecular Weight

501.38

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

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Alternative Products

Catalog	Name
HY-169177	JNK-1-IN-4
HY-14411	JNK-1-IN-1
MBS5821151	JNK-1-IN-2
GTR19239147-01	JNK-1-IN-3
HY-170420	JNK-1-IN-5
GTR19258627-01	BRAFV600E/JNK-IN-1
GTR17964314	Jnk-1 Antibody
TBI5186-5MG	JNK-IN-8, JNK inhibitor
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JNK-1-IN-4

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