Anticancer agent 135

Anticancer agent 135

• CAS Number: 9007-83-4
• UNSPSC Description: Anticancer agent 135 (compound 26h) is a potent androgen receptor (AR) antagonist. Anticancer agent 135 can effectively block AR nuclear translocation and inhibit AR/AR-V7 heterodimerization, thereby inhibiting downstream gene transcription. Anticancer agent 135 displays potent robust efficacy in prostate cancer xenograft models[1].
• Target Antigen: Androgen Receptor
• Type: Reference compound
• Related Pathways: Vitamin D Related/Nuclear Receptor
• Applications: Cancer-programmed cell death
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/anticancer-agent-135.html
• Solubility: 10 mM in DMSO
• Smiles: FC(F)(C1=C(C=CC(N2C(N(CC2=O)CCCN3C4=CC=CC=C4CCC3)=S)=C1)C#N)F
• Molecular Weight: 458.50
• References & Citations: [1]Xiujin Chang, et al. Discovery of thiohydantoin based antagonists of androgen receptor with efficient degradation for the treatment of prostate cancer. Eur J Med Chem. 2023 Sep 5;257:115490.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported