Metallo-β-lactamase-IN-11

Metallo-β-lactamase-IN-11

• UNSPSC Description: Metallo-β-lactamase-IN-11 (compound 5f) is a Metallo-β-lactamases (MBLs) inhibitor, potent against bacterial metallophyllactamase CphA (IC50=45 µM). Metallo-β-lactamase-IN-11 (10 µM) inhibits NDM-1 by 49% and AIM-1 by 61%. Metallo-β-lactamase-IN-11 can be used in the research of inhibiting antibiotic resistance[1].
• Target Antigen: Bacterial; Beta-lactamase
• Type: Reference compound
• Related Pathways: Anti-infection
• Applications: COVID-19-immunoregulation
• Field of Research: Infection
• Assay Protocol: https://www.medchemexpress.com/metallo-β-lactamase-in-11.html
• Solubility: 10 mM in DMSO
• Smiles: N#CC1=C(/N=C/C2=CC=C(O)C=C2)N(CC3=CC=CC=C3)C(C4=CC=CC=C4)=C1C5=CC=CC=C5
• Molecular Weight: 453.53
• References & Citations: [1]Kurz JL, et al. Inhibitors for metallo-β-lactamases from the B1 and B3 subgroups provide an avenue to combat a major mechanism of antibiotic resistance. Bioorg Med Chem Lett. 2023 Jun 25;92:129387.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported