Metallo-β-lactamase-IN-11

• UNSPSC Description:

  Metallo-β-lactamase-IN-11 (compound 5f) is a Metallo-β-lactamases (MBLs) inhibitor, potent against bacterial metallophyllactamase CphA (IC50=45 µM). Metallo-β-lactamase-IN-11 (10 µM) inhibits NDM-1 by 49% and AIM-1 by 61%. Metallo-β-lactamase-IN-11 can be used in the research of inhibiting antibiotic resistance[1].

• Target Antigen:

  Bacterial; Beta-lactamase

• Type:

  Reference compound

• Related Pathways:

  Anti-infection

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Infection

• Assay Protocol:

  https://www.medchemexpress.com/metallo-β-lactamase-in-11.html

• Solubility:

  10 mM in DMSO

• Smiles:

  N#CC1=C(/N=C/C2=CC=C(O)C=C2)N(CC3=CC=CC=C3)C(C4=CC=CC=C4)=C1C5=CC=CC=C5

• Molecular Weight:

  453.53

• References & Citations:

  [1]Kurz JL, et al. Inhibitors for metallo-β-lactamases from the B1 and B3 subgroups provide an avenue to combat a major mechanism of antibiotic resistance. Bioorg Med Chem Lett. 2023 Jun 25;92:129387.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported