Anticancer agent 154

• Description :

  Anticancer agent 154 (Compound 8h) increases the levels of reactive oxygen species and leads to mitochondrial damage. Anticancer agent 154 induces cell apoptosis and DNA damage. Anticancer agent 154 also induces ferroptosis by reducing the GSH level and GPX4 expression and increasing the lipid peroxidation level. Anticancer agent 154 inhibits cancer cell (HT29, H1975, A549, and MCF-7) proliferation with IC50s of 1.0-1.9 μM[1].

• CAS Number :

  [9007-83-4]

• UNSPSC :

  12352005

• Target :

  Apoptosis; Ferroptosis; Reactive Oxygen Species (ROS)

• Type :

  Reference compound

• Related Pathways :

  Apoptosis; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/anticancer-agent-154.html

• Solubility :

  10 mM in DMSO

• Smiles :

  O=C(C=C1)N2C3=CC=CC=C3C4=C2C1=NC(C(NCCN5CCN(C)CC5)=O)=C4

• Molecular Formula :

  C22H23N5O2

• Molecular Weight :

  389.45

• References & Citations :

  [1]Ding J, et al. Novel Canthin-6-one Derivatives: Design, Synthesis, and Their Antiproliferative Activities via Inducing Apoptosis, Deoxyribonucleic Acid Damage, and Ferroptosis. ACS Omega. 2023 Aug 18;8 (34) :31215-31224.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported