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Antiproliferative agent-30

CAT: 0804-HY-155112Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-155112Size:1 Each
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Description
Antiproliferative agent-30 (Compound 8g) inhibits tubulin assembly and inhibits FLT3 and Abl1. Antiproliferative agent-30 has vascular-disrupting activity. Antiproliferative agent-30 has broad antiproliferative activities against cancer cell lines (IC50s: 0.054 nM, 0.008 nM, 0.144 nM for HCT-116, K562, MV-4-11 cells respectively) . Antiproliferative agent-30 also has anticancer effect against AML with FLT3-ITD-TKD mutation[1].
CAS Number
2713553-88-7
UNSPSC
12352005
Target
Bcr-Abl; FLT3; Microtubule/Tubulin
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Cytoskeleton; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/antiproliferative-agent-30.html
Solubility
10 mM in DMSO
Smiles
CC1=C(NCCO)C=C(C2=CN=C3C(C(C4=CC(OC)=C(OC)C(OC)=C4)=NN3)=C2)C=C1
Molecular Formula
C24H26N4O4
Molecular Weight
434.49
References & Citations
[1]Chengqing Ning, et al. Design, synthesis, and biological evaluation of 3, 5-disubsituted-1H-pyrazolo[3,4-b]pyridines as multiacting inhibitors against microtubule and kinases. European Journal of Medicinal Chemistry. Volume 259, 5 November 2023, 115687.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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