DNMT2-IN-2

CAT: 0804-HY-175594Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-175594Size:1 Each
Selected
PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Product image 1
1 / 1
Description
DNMT2-IN-2 is a selective DNA methyltransferase 2 (DNMT2) inhibitor with a KD value of 3.04 μM. DNMT2-IN-2 targets to a cryptic allosteric binding site of DNMT2. DNMT2-IN-2 reduces m5C levels in MOLM-13 tRNA and synergizes with Doxorubicin (HY-15142A) to impair cell viability. DNMT2-IN-2 can be used for cancer research, such as cervical cancer and leukemia[1].
UNSPSC
12352100
Target
DNA Methyltransferase
Related Pathways
Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Smiles
NC(CNC(C[C@H](NC(C1(CC1)CNC(C2=CC(CC)=CC=C2)=O)=O)CC3=CC=C(C=C3)Cl)=O)=O
Molecular Formula
C26H31ClN4O4
Molecular Weight
499.00
References & Citations
[1]Frey AF, et al. DNA-encoded library screening uncovers potent DNMT2 inhibitors targeting a cryptic allosteric binding site. iScience. 2025 Aug 5;28 (9) :113300.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Related Products

CatalogName
HY-154867DNMT2-IN-1
HY-P86854-01Dnmt2 Antibody (YA6547, Rabbit)
HY-P75711DNMT2, Human (sf9, GST)
HY-175988DNMT/HDAC-IN-2
HY-132583IONIS-DNM2-2.5Rx
HY-132583A-01IONIS-DNM2-2.5Rx (sodium)
HY-W011060-01Cryptand 2.2.2
HY-B1500-012,2,2-Trichloroethanol
HY-W0733142,2,2-Trifluoroethoxyamine (hydrochloride)
HY-N2048-012,2':5',2''-Terthiophene

Alternative Products

CatalogName
T212371-01DNMT2-IN-2
PHY3499ADNMT2 Antibody
YF-PA11402anti-DNMT2
508858DNMT2 discontinued
T209575-01DNMT2-IN-1
sc-271513Dnmt2 (A-7)
abx123093-01DNA Methyltransferase 2 (DNMT2) Antibody
219692DNA Methyltransferase 2 (DNMT2) discontinued
abx693096Human DNA Methyltransferase 2 (DNMT2) Protein
NB200-587Mouse Monoclonal Dnmt2 Antibody (102B1259.2)

Popular Products