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S-Gem

CAT: 0804-HY-154842Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-154842Size:1 Each
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Description
S-Gem is a TrxR-dependent prodrug of Gemcitabine (HY-17026) and selectively activated by TrxR. S-Gem shows less cytotoxicity compared to Gemcitabine[1].
CAS Number
[2169925-98-6]
UNSPSC
12352005
Target
Apoptosis; Autophagy; DNA/RNA Synthesis; Nucleoside Antimetabolite/Analog
Type
Reference compound
Related Pathways
Apoptosis; Autophagy; Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/s-gem.html
Solubility
10 mM in DMSO
Smiles
FC1([C@H](N2C(N=C(C=C2)NC(OC3CSSC3)=O)=O)O[C@@H]([C@H]1O)CO)F
Molecular Formula
C13H15F2N3O6S2
Molecular Weight
411.40
References & Citations
[1]Li X, et, al. Combination of chemotherapy and oxidative stress to enhance cancer cell apoptosis. Chem Sci. 2020 Feb 25;11 (12) :3215-3222.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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