S-Gem

• Description:

  S-Gem is a TrxR-dependent prodrug of Gemcitabine (HY-17026) and selectively activated by TrxR. S-Gem shows less cytotoxicity compared to Gemcitabine[1].

• UNSPSC:

  12352005

• Target:

  Apoptosis; Autophagy; DNA/RNA Synthesis; Nucleoside Antimetabolite/Analog

• Type:

  Reference compound

• Related Pathways:

  Apoptosis; Autophagy; Cell Cycle/DNA Damage

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/s-gem.html

• Solubility:

  10 mM in DMSO

• Smiles:

  FC1([C@H](N2C(N=C(C=C2)NC(OC3CSSC3)=O)=O)O[C@@H]([C@H]1O)CO)F

• Molecular Formula:

  C13H15F2N3O6S2

• Molecular Weight:

  411.40

• References & Citations:

  [1]Li X, et, al. Combination of chemotherapy and oxidative stress to enhance cancer cell apoptosis. Chem Sci. 2020 Feb 25;11 (12) :3215-3222.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  [2169925-98-6]