RegisterLogin

GEM-5

CAT: 0804-HY-146540Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-146540Size:1 Each
Selected
PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Product image 1
1 / 1
Description
GEM-5 is a gemcitabine-based conjugate containing a HIF-1α inhibitor (YC-1) (IC50=30 nM) . GEM-5 can significantly down-regulate the expression of HIF-1α and up-regulate the expression of tumor suppressor p53. GEM-5 induces the apoptosis of A2780 cells and inhibits tumor growth[1].
CAS Number
[2233543-49-0]
UNSPSC
12352005
Target
Apoptosis; HIF/HIF Prolyl-Hydroxylase; MDM-2/p53
Type
Reference compound
Related Pathways
Apoptosis; Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/gem-5.html
Solubility
10 mM in DMSO
Smiles
NC(C=CN1[C@@H]2O[C@@H]([C@H](C2(F)F)O)COC(CCC(OCC3=CC=C(O3)C4=NN(C5=C4C=CC=C5)CC6=CC=CC=C6)=O)=O)=NC1=O
Molecular Formula
C32H29F2N5O8
Molecular Weight
649.60
References & Citations
[1]Xu Z, et al. A gemcitabine-based conjugate with enhanced antitumor efficacy by suppressing HIF-1α expression under hypoxia. Bioorg Med Chem. 2021;41:116214.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Related Products

CatalogName
HY-145441GEM–IB
HY-148827GEM-231
HY-154842S-Gem
HY-154843C-Gem
HY-148827AGEM-231 (sodium)
HY-RS16833Gem Mouse Pre-designed siRNA Set A
HY-RS23275Gem Rat Pre-designed siRNA Set A
HY-RS05366GEM Human Pre-designed siRNA Set A
HY-160457-01FABP4/5-IN-5
HY-1494765-LOX-IN-5

Alternative Products

CatalogName
MBS5816483GEM-5
MBS9125260-01GEM
abx233420Gem Associated Protein 5 (GEMIN5) Antibody
bs-13331R-Cy5.5GEM Polyclonal Antibody, Cy5.5 Conjugated
abx320347-01GTP Binding Protein GEM (GEM) Antibody
318152-01GEM (GTP-binding Protein GEM, KIR)
abx616800GTP Binding Protein GEM (GEM) Peptide
536701-01GEM discontinued
C43895-01GEM Antibody
ABC-TC023SGEM-199

Popular Products