5-(Aminomethyl)-2′,3′-O-(1-methylethylidene)-2-thiouridine

5-(Aminomethyl)-2′,3′-O-(1-methylethylidene)-2-thiouridine

• CAS Number: 1428903-07-4
• UNSPSC Description: 5-(Aminomethyl)-2′,3′-O-(1-methylethylidene)-2-thiouridine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].
• Target Antigen: Nucleoside Antimetabolite/Analog
• Type: Oligonucleotides
• Related Pathways: Cell Cycle/DNA Damage
• Applications: Cancer-programmed cell death
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/5-aminomethyl-2-3-o-1-methylethylidene-2-thiouridine.html
• Solubility: 10 mM in DMSO
• Smiles: OC[C@@H]1[C@@H](OC(C)(C)O2)[C@@H]2[C@H](N3C=C(CN)C(NC3=S)=O)O1
• Molecular Weight: 329.37
• References & Citations: [1]Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported