2',3',5'-Tri-O-acetyl-2-thiouridine

• UNSPSC Description:

  2',3',5'-Tri-O-acetyl-2-thiouridine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].

• Target Antigen:

  Nucleoside Antimetabolite/Analog

• Type:

  Oligonucleotides

• Related Pathways:

  Cell Cycle/DNA Damage

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/2-3-5-tri-o-acetyl-2-thiouridine.html

• Solubility:

  DMSO : 250 mg/mL (ultrasonic)

• Smiles:

  O=C(C=C1)NC(N1[C@@H]2O[C@H](COC(C)=O)[C@@H](OC(C)=O)[C@H]2OC(C)=O)=S

• Molecular Weight:

  386.38

• References & Citations:

  [1]Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88.

• Shipping Conditions:

  Room Temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  28542-31-6