5-Hydroxymethyl-2',3'-O-isopropylidene-2-thiouridine

5-Hydroxymethyl-2',3'-O-isopropylidene-2-thiouridine

• CAS Number: 58479-71-3
• UNSPSC Description: 5-Hydroxymethyl-2',3'-O-isopropylidene-2-thiouridine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].
• Target Antigen: Nucleoside Antimetabolite/Analog
• Type: Oligonucleotides
• Related Pathways: Cell Cycle/DNA Damage
• Applications: Cancer-programmed cell death
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/5-hydroxymethyl-2-3-o-isopropylidene-2-thiouridine.html
• Solubility: 10 mM in DMSO
• Smiles: O=C(C(CO)=C1)NC(N1[C@@H]2O[C@H](CO)[C@@H]3[C@H]2OC(C)(C)O3)=S
• Molecular Weight: 330.36
• References & Citations: [1]Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported