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TLR7 agonist 13

CAT: 0804-HY-154361Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-154361Size:1 Each
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Description
TLR7 agonist 13 is a guanosine analog. Some guanosine analogs have immunostimulatory activity. In some animal models, they also induce type I interferons, producing antiviral effects. Studies have shown that the functional activity of guanosine analogs is dependent on the activation of Toll-like receptor 7 (TLR7) [1]. TLR7 agonist 13 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
CAS Number
2389988-70-7
UNSPSC
12352005
Target
Nucleoside Antimetabolite/Analog
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/tlr7-agonist-13.html
Solubility
10 mM in DMSO
Smiles
O=C1N(CC#C)C2=C(N=C(N)N=C2)N1[C@@H]3O[C@H](COC(C)=O)C[C@H]3OC(C)=O
Molecular Formula
C17H19N5O6
Molecular Weight
389.36
References & Citations
[1]Lee J, et al. Molecular basis for the immunostimulatory activity of guanine nucleoside analogs: activation of Toll-like receptor 7. Proc Natl Acad Sci U S A. 2003 May 27;100 (11) :6646-51.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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