Edonentan

CAT: 0804-HY-15402Size: 1 mgDry Ice: NoHazardous: No
CAT#:0804-HY-15402Size:1 mg
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Description
Edonentan (BMS 207940) is an antagonist for endothelin receptor (ETA receptor), with a Ki of 10 pM. Edonentan is metabolic stable, exhibits good pharmakokinetic characters in rats. Edonentan regulates the endothelin system, blocks the big Endothelin-induced pressor response in rats model[1].
CAS Number
[210891-04-6]
Product Name Alternative
BMS 207940
UNSPSC
12352005
Target
Endothelin Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/edonentan.html
Smiles
CC(C)(C)CC(N(CC1=CC(C2=NC=CO2)=CC=C1C3=CC=CC=C3S(=O)(NC4=NOC(C)=C4C)=O)C)=O
Molecular Formula
C28H32N4O5S
Molecular Weight
536.64
References & Citations
[1]Murugesan N, et al., Biphenylsulfonamide endothelin receptor antagonists. 4. Discovery of N-[[2'-[[ (4,5-dimethyl-3-isoxazolyl) amino]sulfonyl]-4- (2-oxazolyl) [1,1'-biphenyl]- 2-yl]methyl]-N,3,3-trimethylbutanamide (BMS-207940), a highly potent and orally active ET (A) selective antagonist. J Med Chem. 2003 Jan 2;46 (1) :125-37.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
ETA; ETB

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