ML 2-23

• UNSPSC Description:

  ML 2-23 is a potent PROTAC BCR-ABL degrader. ML 2-23 is selectively degrade BCR-ABL in a proteasome-dependent manner in leukemia cells[1].

• Target Antigen:

  Bcr-Abl; PROTACs

• Type:

  Reference compound

• Related Pathways:

  PROTAC;Protein Tyrosine Kinase/RTK

• Applications:

  Cancer-Kinase/protease

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/ml-2-23.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C(COC1=CC=C(C2CC(C3=CC=C(Br)C=C3)=NN2C(CCl)=O)C=C1)NCCOCCOCCOCCN4CCN(C5=NC(C)=NC(NC6=NC=C(C(NC7=C(C)C=CC=C7Cl)=O)S6)=C5)CC4

• Molecular Weight:

  1052.86

• References & Citations:

  [1]Luo M, et, al. Chemoproteomics-enabled discovery of covalent RNF114-based degraders that mimic natural product function. Cell Chem Biol. 2021 Apr 15;28(4):559-566.e15.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported