ML 2-23

• Description :

  ML 2-23 is a potent PROTAC BCR-ABL degrader. ML 2-23 is selectively degrade BCR-ABL in a proteasome-dependent manner in leukemia cells[1].

• UNSPSC :

  12352005

• Target :

  Bcr-Abl; PROTACs

• Type :

  Reference compound

• Related Pathways :

  PROTAC; Protein Tyrosine Kinase/RTK

• Applications :

  Cancer-Kinase/protease

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/ml-2-23.html

• Solubility :

  10 mM in DMSO

• Smiles :

  O=C(COC1=CC=C(C2CC(C3=CC=C(Br)C=C3)=NN2C(CCl)=O)C=C1)NCCOCCOCCOCCN4CCN(C5=NC(C)=NC(NC6=NC=C(C(NC7=C(C)C=CC=C7Cl)=O)S6)=C5)CC4

• Molecular Formula :

  C47H53BrCl2N10O7S

• Molecular Weight :

  1052.86

• References & Citations :

  [1]Luo M, et, al. Chemoproteomics-enabled discovery of covalent RNF114-based degraders that mimic natural product function. Cell Chem Biol. 2021 Apr 15;28 (4) :559-566.e15.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported